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Glioblastoma is common among elderly patients, a group in which comorbidities and a poor prognosis raise important considerations when designing neuro‐oncologic care. Although the standard of care for nonelderly patients with glioblastoma includes maximal safe surgical resection followed by radiotherapy with concurrent and adjuvant temozolomide, the safety and efficacy of these modalities in elderly...
BACKGROUNDAlthough screening for colorectal cancer (CRC) is a widely accepted concept nationally and screening rates are increasing, there are differences in screening rates between states and within states.
METHODSIn an effort to increase screening rates and ensure equal access with respect to race/ethnicity, the New York City Department of Health and Mental Hygiene formed a coalition of stakeholders...
BACKGROUNDMarital status, income, and education might influence the risk of esophageal and gastric cancer, but the literature is limited. A large study addressing subtypes of these tumors was used to clarify these associations.
METHODSA nationwide, Swedish population–based cohort study from 1991 to 2010 included individuals who were 50 years old or older. Data on exposures, covariates, and outcomes...
BACKGROUNDBilaterality is common in papillary thyroid cancer (PTC), but its clinical and prognostic implications are still controversial, and it remains unclear whether its behavior is more aggressive than multifocality.
METHODSThe clinicopathologic features of 2211 consecutive patients with PTC who underwent surgical treatment at the authors’ institute between 1997 and 2011 were reviewed. Among...
BACKGROUNDRisk factors for the development of therapy‐related leukemia (TRL), an often lethal late complication of cytotoxic therapy, remain poorly understood and may differ for survivors of different malignancies. Survivors of breast cancer (BC) now account for the majority of TRL cases, making the study of TRL risk factors in this population a priority.
METHODSSubjects with TRL after cytotoxic...
BACKGROUNDThe validity of the Distress Thermometer (DT) as a screen for psychological distress in young adult cancer survivors was assessed by comparing it with the results of a psychiatric diagnostic interview, the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM‐IV) (SCID), to evaluate the accuracy of the DT and identify optimal cutoff...
BACKGROUNDThere is a debate regarding the management of ovarian immature teratomas (ITs). In adult women, postoperative chemotherapy is standard except for stage I, grade 1 disease, whereas surgery alone is standard in pediatric patients. To determine the role of chemotherapy, a pooled analysis of pediatric and adult clinical trials was conducted.
METHODSData from 7 pediatric trials and 2 adult trials...
BACKGROUNDThe authors hypothesized that comprehensive genomic profiling of advanced‐stage cutaneous squamous cell carcinoma (cSCC) could identify genomic‐derived drug targets of therapy for patients with conventional therapy‐resistant disease.
METHODSComprehensive genomic profiling of 315 cancer genes was applied to 50 ng of DNA from 122 cSCC cases for the evaluation of all classes of genomic alterations...
BACKGROUNDThe current study was conducted to determine the effect of continuing a centralized fecal occult blood test (FOBT) mailed program on screening adherence.
METHODSA patient‐level randomized controlled trial was conducted in 21 patient‐centered medical home primary care clinics between January 2010 and November 2012. A total of 2208 patients ranging in age from 52 to 75 years in a substudy...
BACKGROUNDPatients who receive adjuvant chemotherapy have reported cognitive impairments that may last for years after the completion of treatment. Working memory‐related and long‐term memory‐related changes in this population are not well understood. The objective of this study was to demonstrate that cancer‐related cognitive impairments are associated with the under recruitment of brain regions...
BACKGROUNDTyrosine kinase inhibitors (TKIs) significantly improve survival in patients with chronic myeloid leukemia in chronic phase (CML‐CP). Conditional probability provides survival information in patients who have already survived for a specific period of time after treatment.
METHODSCumulative response and survival data from 6 consecutive frontline TKI clinical trials were analyzed. Conditional...
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